Curriculum Vitae of

P.O. Box 158

Midway, TX 75852-0158

Phone: (979) 450-2599

E-mail: brad@ovitra.com

Web: http://www.ovitra.com

Brad R. Lindsey, Ph.D.

Education	Sep. 1994 – Dec. 1998. University of Nebraska, Lincoln, NE Ph.D. / Animal Science / Physiology / Reproductive Endocrinology / Advisor: Dr. Jim Kinder Dissertation: "Exogenous Hormonal Control of Gonadotropin Release Affecting Dominant, Persistent, and Superstimulated Ovarian Follicle Development in Cattle" May 1982 - Dec. 1984. Texas A&M University, College Station, TX M.Agr. / Animal Science / Equine Reproduction / Advisor: Dr. Jack Kreider Thesis: "Recipient mare management for commercialized embryo transfer" Aug. 1978 – May 1982. Texas A&M University, College Station, TX B.S. / Agricultural Economics / Agribusiness
Professional Experience	Aug. 2005 – Present. Founder / CEO, Ovitra Biotechnology, Inc. (formerly Rex Consulting) Midway, TX Sep. 2004 – Jul.2005. General Manager, Female Reproductive Services. Genetic Resources Int’l / Navasota, TX / Supervisor: Juan Moreno, Owner/CEO Jul. 2002 – Aug. 2004. Director of Bovine Biotech Product Development. Minitube of America / Verona, WI / Supervisor: Ludwig Simmet, Owner/CEO Mar. 2000 – Jun. 2002. Senior Scientist, Research & Development. AB Technology, Inc. / Pullman, WA / Supervisor: Trevor Steel, CEO Jun. 1998 – Mar. 2000. General Manager. Stroud Veterinary Embryo Services / Weatherford, TX / Supervisor: Brad K. Stroud, DVM, Owner Sep. 1997 - Mar. 1998. Research Associate. Tropical Beef Centre / Rockhampton, Queensland, Australia / Supervisor: Michael D’Occhio, PhD, Professor May 1995 – Aug. 1997. Research Technician II. University of Nebraska / Animal Science Dept. / Lincoln, NE / Supervisor: Jim Kinder, PhD, Professor Jan. 1992 - Aug. 1994. Director - IVF Services. Trans Ova Genetics / Sioux Center, IA / Supervisor: Dave Faber, DVM, Owner/CEO Sep. 1988 – Dec. 1991. Production Laboratory Supervisor / Embryologist. Granada BioSciences / Genetics Div. / Marquez, TX / Supervisors: Mike Wilson, PhD, GM / Joe Oden, DVM, GM Dec. 1983 - Aug. 1988. Reproductive Physiologist. Granada Equine Services / Reproductive Lab / Wheelock, TX / Supervisor: Steve Vogelsang, MS, GM
Professional Affiliations, & Committees	§ International Embryo Transfer Society (member) § Research & Technology Sub-Committee of Companion Animal, Non-Domestic, & Endangered Species Committee § Local Organizing Committee Chairman for Portland 2004 Annual Meeting § American Embryo Transfer Association (member) § Chairman, Newsletter Committee § Member, Certification Committee · Adjunct Professor, Dept. of An. Sci. WSU-Pullman, WA / 2000-2002 · Adjunct Professor, Dept. of An. Sci. UW-Madison, WI / 2002-2004
Invited Presentations	Oct. 2008 / Speaker / AETA Pre-Conference Seminar / Topic: Emerging Technologies / Kansas City, Missouri, USA Nov. 2006 / Speaker / PBR Finals / Topic: Reproductive Technologies for Bucking Stock / Las Vegas, Nevada, USA Aug. 2003 / Speaker / AETS Main Program / Topic: Improving Embryo Media Quality and Microenvironment / Brisbane, Queensland, Australia Oct. 2002 / Speaker / AETA Main Program / Topic: Recent Advancements in Embryo Media and Related Technologies / Albuquerque, NM, USA Sep. 2002 / Speaker / AABP Pre-Conference Seminar / Topic: Embryo Media and Applied Research Strategies / Madison, WI, USA Aug. 2002 / Speaker, Panelist / CETA / Topic: Applied Embryo Research Strategies / Quebec City, Quebec, Canada Jun. 2001 / Speaker / CRB Annual Retreat / Topic: Exogenous Control of Gonadotropin Release During Ovarian Superstimulation in Cattle / Couer d’Alene Lake, ID, USA Sep. 2000 / Instructor / AABP Pre-Conference Seminar / Topic: Embryo Micro-manipulation & Gender Determination / Rapid City, SD, USA Aug. 1999 / Speaker / CETA Main Program / Topics: The Role of FSH and LH in Ovarian Follicular Development in Cattle and A GnRH Agonist Model for Superovulation in Cattle / London, Ontario, Canada Oct. 1998 / Speaker / AETA Main Program / Topic: GnRH Agonist Model for Superovulation / San Antonio, TX, USA Aug. 1996 / Instructor / Partners of the Americas / Federal University of Piaui / Seminar & Workshop: Bovine ET Methodology / Teresina, Piaui, Brazil Jan. 1994 / Panelist / IETS Annual Meeting / Topic: Commercial Bovine IVF Techniques / Melbourne, Victoria, Australia Jan. 1992 / Instructor / IETS Annual Meeting / Workshop: Oocyte Retrieval Procedures / CSU Foothills Campus, Ft. Collins, CO, USA
Publications	Vogelsang, M.M., S.G. Vogelsang, B.R. Lindsey and J.M. Massey. 1989. Reproductive performance of mares subjected to routine examination by diagnostic ultrasound. Theriogenology 32:95-103. Looney, C.R., B.R. Lindsey, C.L. Gonseth and D.L. Johnson. 1994. Commercial aspects of oocyte retrieval and in vitro fertilization (IVF) for embryo production in problem cows. Theriogenology 41:67-72. Splan, R.K., B.R. Pilcik, U.J. Tomsen, J.A.G. Arango, A. Ruiz-Flores, J.W. Hallock, M.F. Allan, S.K.R. Karnati, V. Vega, B.R. Lindsey, D.E. Moody and D. Pomp. 1998. Rapid Communication: Mapping of the steroidogenic acute regulatory protein (StAR) gene to porcine chromosome 15 by linkage analysis using a novel PCR-RFLP. J. Anim. Sci. 76:658-659. Melvin, E.J., B.R. Lindsey, J. Quintal-Franco, E. Zanella, K.E. Fike, C.P. VanTassell, and J.E. Kinder. 1999. Circulating concentrations of estradiol, luteinizing hormone, and follicle stimulating hormone during waves of ovarian follicular development in prepubertal cattle. Biol. Reprod. 60:405-412. Fike, K.E., M.E. Wehrman, B.R. Lindsey, E.G. Bergfeld, E.J. Melvin, J.A. Quintal, E.L. Zanella, F.N. Kojima, and J.E. Kinder. 1999. Estrus synchronization of beef cattle with a combination of melengestrol acetate and an injection of progesterone and 17beta-estradiol. J Anim Sci 77:715-723. D’Occhio, M.J., D. Jillella and B.R. Lindsey. 1999. Factors that influence follicle recruitment, growth and ovulation during ovarian superstimulation in heifers: opportunities to increase ovulation rate and embryo recovery by delaying the exposure of follicles to LH. Theriogenology 51:9-35 (Review). Quintal-Franco, J.A., F.N. Kojima, E.J. Melvin, B.R. Lindsey, E. Zanella, K.E. Fike, M.E. Wehrman, D.T. Clopton and J.E. Kinder. 1999. Corpus luteum development and function in cattle with episodic release of luteinizing hormone pulses inhibited in the follicular and early luteal phases of the estrous cycle. Biol Reprod. 61:921-926. Rorie, R.W., T.D. Lester, B.R. Lindsey, and R.W. McNew. 1999. Effect of timing of artificial insemination on gender ratio in beef cattle. Theriogenology 52:1035-1041. Hammer, C.J., H.D. Tyler, L.M. Loskutoff, D.L. Armstrong, D.J. Funk, B.R. Lindsey, and L.G. Simmons. 2001. Compromised development of calves (Bos gaurus) derived from in vitro-generated embryos and transferred interspecifically into domestic cattle (Bos taurus). Theriogenology 55(7):1447-55. Lindsey, B.R., L.J. Maclellan, T.R. Whyte, J.E. Kinder and M.J. D'Occhio. 2002. Differential requirement for pulsatile LH during the follicular phase and exposure to the preovulatory LH surge for oocyte fertilization and embryo development in cattle. Theriogenology 58(9):1651-1662. Lindsey, B.R., K.E. Fike, J.A. Quintal, E.L. Zanella, J.W. Koch, L.R. Ehnis, and J.E. Kinder. Antagonist of gonadotropin hormone-releasing hormone suppression of follicle stimulating hormone (FSH) is dependent on concentration of FSH at time of administration in cattle. Biol. Reprod. (in-progress). Lindsey, B.R., M.E. Wehrman, E.J. Melvin, J.A. Quintal, F.N. Kojima, E.L. Zanella, K.E. Fike, E.G.M. Bergfeld, and J.E. Kinder. Ovarian follicular growth and endocrine responses following a single injection of progesterone in cows (in-progress). Lindsey, B.R., M.E. Wehrman, E.J. Melvin, J.A. Quintal, F.N. Kojima, E.L. Zanella, K.E. Fike, E.G.M. Bergfeld, and J.E. Kinder. Effects of increased duration of endogenous LH pulses during superovulation in cattle on circulating hormones, ovarian follicular growth, intrafollicular steroids, oocyte maturation and embryo development (in-progress). Lindsey, B.R., M.E. Wehrman, J.A. Quintal, E.J. Melvin, E.L. Zanella, K.E. Fike, F.N. Kojima, and J.E. Kinder. Effect of duration of exposure to low LH pulse frequencies on development and biochemical characteristics of persistent ovarian follicles and on circulating hormones in beef cows (in-progress).
Symposia / Proceedings / Abstracts	Lindsey, B.R., C.R. Looney, D.J. Funk, D.C. Faber, C.S. Gue and A.J. Kramer. 1994. The effect of apparent dominant follicle removal (DFR) prior to FSH treatment on superstimulated response. Proceedings IETS Annual Meeting. Theriogenology 41(1):238. Armstrong, D.L., C.R. Looney, B.R. Lindsey, C.L. Gonseth, D.L. Johnson, K.R. Williams, L.G. Simmons and N.M. Loskutoff. 1995. Transvaginal egg retrieval and in vitro embryo production in guar (Bos guarus) with establishment of interspecies pregnancy. Proceedings IETS Annual Meeting. Theriogenology 43(1):162. Looney, C.R., P. Damiani, B.R. Lindsey, C.R. Long, C.L. Gonseth, D.L. Johnson, and R.T. Duby. 1995. Use of prepuberal heifers as oocyte donors for IVF: Effect of age and gonadotropin treatment. Proceedings IETS Annual Meeting. Theriogenology 43(1):267. Paul, J.B., C.R. Looney, B.R. Lindsey and R.A. Godke. 1995. Gonadotropin stimulation of cattle donors at estrus for transvaginal oocyte collection. Proceedings IETS Annual Meeting. Theriogenology 43(1):295. Lindsey, B.R., M.E. Wehrman, E.J. Melvin, J.A. Quintal, F.N. Kojima, E.L. Zanella, K.E. Fike, E.G.M. Bergfeld, and J.E. Kinder. 1995. Ovarian follicular growth and FSH secretion following a timed injection of progesterone in cows. Proceedings IETS Annual Meeting. Theriogenology 45(1):328. Melvin, E.J., B.R. Lindsey, J.A. Quintal-Franco, E. Zanella, C.P. VanTassell, K.E. Fike, and J.E. Kinder. 1996. Patterns of ovarian follicular growth following follicle ablation in heifers form eight to one month prepuberty. Proceedings SSR Annual Meeting. Biol. Reprod. 54:178. Fike, K.E., M.E. Wehrman, B.R. Lindsey, E.G. Bergfeld, E.J. Melvin, J.A. Quintal, E.L. Zanella, and J.E. Kinder. 1997. Estrous synchronization in beef cattle with melengesterol acetate (MGA) and an injection of progesterone (P4). Proceedings ASAS Annual Meeting. J. An. Sci. 75:232. Jimenez-Severiano, H., J. Quintal-Franco, V. Vega-Murillo, E. Zanella, M.E. Wehrman, B.R. Lindsey, E.J. Melvin and J.E. Kinder. 1997. Response of testis of bulls to LH during different seasons of the year. Proceedings SSR Annual Meeting. Biol. Reprod. 56:112. Fike, K.E., F.N. Kojima, E.G. Bergfeld, B.R. Lindsey, E.J. Melvin, J.A. Quintal, E.L. Zanella, M.E. Wehrman, and J.E. Kinder. 1997. Magnitude of shift in concentration of progesterone (P4) in circulation does not alter LH secretion to the same extent as absolute concentrations of P4 in heifers. Proceedings SSR Annual Meeting. Biol. Reprod. 56:120. Lindsey, B.R., M.E. Wehrman, E.J. Melvin, J.A. Quintal, F.N. Kojima, E.L. Zanella, K.E. Fike, E.G.M. Bergfeld, and J.E. Kinder. 1997. Circulating progesterone and intrafollicular steroid concentrations in dominant ovarian follicles following an injection of progesterone in cows. Proceedings ASAS Annual Meeting. J. An. Sci. 75: 227. Lindsey, B.R., K.E. Fike, J.A. Quintal, E.L. Zanella, J.W. Koch, L.R. Ehnis, and J.E. Kinder. 1997. Effects of LHRH antagonist and bFF on FSH secretion and ovarian follicle development in heifers. Proceedings SSR Annual Meeting. Biol. Reprod. 56:120. Fischer-Brown AE, Lindsey BR, Ireland FA, Northey DL, Monson RL, Clark SG, Wheeler MB, Kesler DJ, Lane SJ, Weigel KA, Rutledge JJ. 2005. Embryonic disc development and subsequent viability of cattle embryos following culture in two media under two oxygen concentrations. Reprod. Fertil. Dev. Jan. 13; 16(8):787-793. Ehnis, L.R., J.W. Koch, B.R. Lindsey, H. Jimenez-Severiano, V.E. Vega-Murillo, H.D. Hafs, and J.E. Kinder. 1998. Efficacy of intravaginal progesterone releasing insert to advance date of estrus and synchronize estrus in post-partum beef cows and peripubertal heifers. Proceedings ASAS Midwest Section Meeting. #167. Ehnis, L.R., J.W. Koch, B.R. Lindsey, H. Jimenez-Severiano, V.E. Vega-Murillo, H.D. Hafs, and J.E. Kinder. 1998. Estrous and ovulation suppression and corpus luteum (CL) function in cows treated with a progesterone releasing intravaginal insert. Proceedings ASAS Midwest Section Meeting. # 166. Lindsey, B.R. 1998. A GnRH agonist model for superovulation in cattle. Proceedings AETA Annual Meeting, 64-74. Clopton, D.T., B.R. Lindsey, A. Clark, A. Klein, and J.E. Kinder. 1999. Duration of treatment with short-term, large doses of progesterone regulates luteinizing hormone receptor and aromatase mRNA content and steroid ratio in persistent ovarian follicles. Proceedings SSR Annual Meeting XX:XXX. Echternkamp, S.E., K.E. Gregory, B.R. Lindsey, M. Mussard, J.E. Kinder. 1999. Comparison of FSH and LH response to follicle aspiration in cattle selected (twinner) and unselected (control) for twin births. Proceedings SSR Annual Meeting XX:XXX. Lindsey, B.R. and J.E. Kinder. 1999. The role of follicle stimulating hormone and luteinizing hormone in ovarian follicular development in cattle. Proceedings CETA / ACTE Annual Meeting, 4. Lindsey, B.R. and M. D’Occhio. 1999. A GnRH model for superovulation in cattle. Proceedings CETA / ACTE Annual Meeting, 5. Rorie, R.W., T.D. Lester, B.R. Lindsey, and R.W. McNew. 1999. Effect of timing of insemination on sex ratio in beef cattle. Proceedings IETS Annual Meeting. Theriogenology 51(1):399. Loskutoff, N.M., D.L. Armstrong, C.L. Ohlrichs, D.L. Johnson, D.J. Funk, P.V. VanRoekel, J.A. Molina, B.R. Lindsey, C.R. Looney, and L.G. Simmons. 2000. Transvaginal, ultrasound-guided oocyte retrieval and the developmental competence of in vitro produced embryos in vitro and in vivo in the Guar (Bos guarus). Proceedings IETS Annual Meeting. Theriogenology 53(1):337. Bader, J.F., F.N. Kojima, M.E. Wehrman, B.R. Lindsey, M.S. Kerley, and D.J. Patterson. 2002. Effects of prepartum lipid supplementation of FSH superstimulation and embryo quality in multiparous beef cows. Proceedings IETS Annual Meeting. Theriogenology 57(1):760. Kojima, F.N., J.F. Bader, B.R. Lindsey, M.E. Wehrman, W.L. Malcolm, J.E. Stenger, and D.J. Patterson. 2002. Evaluation of an estrus synchronization protocol prior to superovulation in beef cows. Proceedings IETS Annual Meeting. Theriogenology 57(1):766. Rozeboom, K.J., B.R. Lindsey, and M.E. Wilson. 2003. Effect of semen extender on oocyte penetration capacity by porcine spermatozoa in vitro. Proceedings IETS Annual Meeting. Theriogenology 59(1):229. Lindsey, B.R., S. Schlee, and S. Terlouw. 2003. Embryo media: quality control analysis and biocompatibility testing. Embryo Transfer Newsletter of the IETS 21 (2):4-11.